Gundy S, Bender M A
Radiat Res. 1984 Mar;97(3):519-25.
We have irradiated human peripheral lymphocytes after various intervals of phytohemagglutin stimulation to determine the time course for exchange induction and to determine whether or not deletion yields increase with increasing intervals of stimulation. We found no increase in deletion yields for intervals up to 12 hr, and rings and dicentric yields increased by about 60% in the interval between 0 and 6 hr but then reached a plateau. We also measured induced unscheduled DNA synthesis during the same interval and found it generally increased during the first 6 hr like exchange yields, but then tended to decrease again.
我们在植物血凝素刺激的不同时间间隔后对人外周血淋巴细胞进行了照射，以确定交换诱导的时间进程，并确定缺失率是否会随着刺激时间间隔的增加而增加。我们发现，在长达12小时的时间间隔内，缺失率没有增加，在0至6小时的时间间隔内，环状染色体和双着丝粒染色体的产率增加了约60%，但随后达到了平台期。我们还在同一时间间隔内测量了诱导性非计划DNA合成，发现它通常在前6小时内像交换产率一样增加，但随后又趋于下降。
