Meslin J C, Sacquet E
Reprod Nutr Dev (1980). 1984;24(3):307-14. doi: 10.1051/rnd:19840309.
The length and diameter of enterocyte microvilli at mid-villus position were measured on electron-micrographs. The duodenum, jejunum and ileum of axenic (germfree) and holoxenic (conventional) inbred rats fed the same diet have been studied. The microvilli were significantly shorter in all these intestinal regions when the microflora was present. The decrease in microvillus length (due to the presence of microflora), expressed as a percentage of the length in axenic rat, was 5% in the duodenum, 9% in the jejunum and 18% in the ileum. This was not true of microvillus diameter where only the values found for the ileum of axenic rat were significantly lower, the others not differing among themselves. In conclusion, the presence of a total microflora led to a decrease in the length of enterocyte microvilli. These results have been discussed in relation with studies on renewal and enzyme activity in the intestinal epithelium.
在电子显微镜照片上测量了肠绒毛中部位置肠上皮细胞微绒毛的长度和直径。对饲喂相同饮食的无菌（无特定病原体）和普通近交系大鼠的十二指肠、空肠和回肠进行了研究。当存在微生物群时，所有这些肠道区域的微绒毛明显更短。微绒毛长度的减少（由于微生物群的存在），以无菌大鼠中长度的百分比表示，十二指肠为5%，空肠为9%，回肠为18%。微绒毛直径则不然，只有无菌大鼠回肠的测量值明显更低，其他部位之间没有差异。总之，完整微生物群的存在导致肠上皮细胞微绒毛长度减少。这些结果已结合肠道上皮更新和酶活性的研究进行了讨论。
