Lin T H, Huang Y L
School of Technology for Medical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan, Republic of China.
Biol Trace Elem Res. 1995 Jun;48(3):251-61. doi: 10.1007/BF02789407.
Blackfoot disease is a peripheral vascular disease resulting in gangrene of the lower extremities. Although extensive epidemiological study has implicated high arsenic content in artesian well water of the endemic area bears some important connection with the disease, the etiology of the disease is still not clarified. In this study, attention is paid to chemical speciation of arsenic in order to find out whether the concentrations of arsenic species in urine of Blackfoot disease patients are different from those of controls. Experimental results indicate that the total arsenic, inorganic arsenic, monomethylarsonic acid, and other forms of arsenic in the urine of patients are significantly higher than those of the controls. The possible connection of those arsenic species with the etiology of the disease is discussed.
乌脚病是一种导致下肢坏疽的周围血管疾病。尽管广泛的流行病学研究表明，流行地区自流井水中的高砷含量与该疾病存在某种重要联系，但该疾病的病因仍未明确。在本研究中，关注砷的化学形态，以查明乌脚病患者尿液中砷形态的浓度是否与对照组不同。实验结果表明，患者尿液中的总砷、无机砷、一甲基胂酸和其他砷形态均显著高于对照组。文中讨论了这些砷形态与该疾病病因的可能联系。
