Piatigorsky J, Fukui H N, Kinoshita J H
Nature. 1978 Aug 10;274(5671):558-62. doi: 10.1038/274558a0.
Ocular lenses in Nakano mice showed marked changes in synthesis, degradation and leakage of protein during cataractogenesis. The cataract-associated changes included the differential lowering of crystallin synthesis, the cleavage of crystallin polypeptides to lower molecular weight forms and the leakage of crystallins from cultured lenses. Ouabain treatment of normal lenses induced these alterations, suggesting that changes in the intracellular levels of Na+ and K+ affect the anabolism and catabolism of protein during cataract formation.
中野小鼠的晶状体在白内障形成过程中，蛋白质的合成、降解和渗漏出现了显著变化。与白内障相关的变化包括晶状体蛋白合成的差异性降低、晶状体蛋白多肽裂解为分子量更低的形式以及培养的晶状体中晶状体蛋白的渗漏。哇巴因处理正常晶状体可诱导这些改变，这表明细胞内Na+和K+水平的变化在白内障形成过程中影响蛋白质的合成代谢和分解代谢。
