Derlon J M, Roy-Camille R, Saillant G, Poirier J, Pichon F
Neurochirurgie. 1978;24(2):103-11.
Twenty-three dogs underwent a complete transection of the spinal cord at L 1 level. Section was followed in eighteen animals by reconstruction effected through suture of the arachnoide with the aid of monofilament 10 X 0 thread. The operation was in all cases concluded by an osteosynthesis with metallic material in order to prevent any movements in the operated site, and a tight dural closure was achieved in order to prevent propagation of any epidural hematoma or secondary granuloma. This technique did not prevent an unfavorable evolution of the suture, which demonstrated three different morphological features:--necrosis of the spinal cord cut ends with secondary formation of a transverse cyst;--secondary infiltration of the operated focus by a fibrous scar growing from the inner aspect of the dura;--failure of axon regeneration through this fibrous block in spite of noteworthy proliferation of axons coming from the dorsal roots. A critical analysis of those results led to a comparaison with various previous works on the same subject. The most recent of these works have led to promising prospects which need confirmation.
23只狗在L1水平接受了脊髓完全横断手术。18只动物在横断后通过借助10X0单丝缝线缝合蛛网膜进行重建。所有病例手术最后均采用金属材料进行骨合成，以防止手术部位出现任何移动，并实现硬膜紧密闭合，以防止硬膜外血肿或继发性肉芽肿扩散。该技术未能阻止缝线出现不良转归，缝线呈现出三种不同的形态特征：脊髓断端坏死并继发形成横向囊肿；手术部位被从硬膜内侧长出的纤维瘢痕继发浸润；尽管来自背根的轴突有明显增生，但轴突未能穿过该纤维性阻滞实现再生。对这些结果进行批判性分析后，将其与之前关于同一主题的各种研究进行了比较。这些研究中最新的研究已带来了需要证实的有前景的结果。
