Systolic time intervals reconsidered. Reevaluation of the preejection period: absence of relation to heart rate.

Within limits, systolic time intervals are reliable reflectors of cardiac status and responses to physiologic and pharmacologic challenges, with various functional correlates. That heart rate (HR) is an important determinant of the duration of systole is well accepted, owing to its effect on left ventricular ejection time (LVET). An independent rate effect on preejection period (PEP) is disputed. Some studies in pooled normal subjects at rest showed some degree of HR-PEP covariance, leading to widespread rate correction in practical use. However, although right atrial pacing showed the expected HR-LVET relation, it consistently failed to show an HR-PEP relation. Systolic time intervals were examined from echocardiograms of a deliberately heterogeneous group comprising 50 consecutively appearing persons with sinus rhythm. There was no HR-PEP covariance (r = 0.23; p = not significant). However, our subjects were otherwise comparable to those of other investigators, in that all other relations in these subjects were as expected from studies in both pooled and paced subjects: HR with LVET (r = -0.74; p less than 0.001), PEP/LVET with ejection fraction (r = -0.85; p less than 0.001), and PEP/LVET with velocity of circumferential fiber shortening (r = -0.65, p less than 0.001). Thus, HR correction of PEP is inappropriate. All other relations are substantiated in routinely encountered, unselected subjects.