Kawakami M, Paul J L, Thurlbeck W M
Am J Anat. 1984 May;170(1):1-21. doi: 10.1002/aja.1001700102.
Morphometric examination using light, scanning electron, and transmission electron microscopy was performed on the lungs from 32 inbred male BALB/ cNNia mice between 38 days and 28 months of age. Between 38 days and 9 months of age the changes were primarily those of growth. Alveolar multiplication and total elastic-fiber length appeared complete by 38 days of age. The major increase in the number of interalveolar pores occurred by 68 days, but there was a significant further increase from 68 days to 9 months of age. At 9 months, approximately 10% of the alveolar wall was formed by pores. Alveolar ducts, the cylindrical core of air central to alveolar mouths, increased more in diameter than length. Between 9 and 28 months the changes were attributed to aging and were different from those reported in humans and other species. Lung volume, alveolar surface area, and total volume of alveolar wall increased with age; there was no change in mean linear intercept and volume proportion of alveolar and alveolar duct air. Total area of pores increased with age, but their number and area fraction of the alveolar wall did not change. No transmission electron microscopic changes were seen in the alveolar walls. We speculate that the morphometric differences between our animals and those studied in other reports may reflect the fact that our animals were specific-pathogen-free animals and kept under protected circumstances.
对32只38天至28个月大的近交系雄性BALB/cNNia小鼠的肺组织进行了光镜、扫描电镜和透射电镜的形态计量学检查。在38天至9个月大之间，变化主要是生长方面的。肺泡增殖和总弹性纤维长度在38日龄时似乎已完成。肺泡间孔数量的主要增加发生在68日龄时，但从68日龄到9个月龄仍有显著进一步增加。在9个月时，约10%的肺泡壁由孔构成。肺泡管是肺泡口中央的圆柱形空气核心，其直径增加比长度增加更多。在9至28个月之间，变化归因于衰老，且与人类和其他物种的报道不同。肺体积、肺泡表面积和肺泡壁总体积随年龄增加；平均线性截距以及肺泡和肺泡管空气的体积比例没有变化。孔的总面积随年龄增加，但其数量和在肺泡壁中的面积分数没有变化。在肺泡壁中未观察到透射电镜下的变化。我们推测，我们的动物与其他报告中所研究动物之间的形态计量学差异可能反映了这样一个事实，即我们的动物是无特定病原体动物且饲养在受保护的环境中。
