Zinchenko T A, Rudzit E A, Zukakova I B, Lisitsa L I
Antibiotiki. 1984 Mar;29(3):214-20.
The chemotherapeutic efficacy of gentamicin, tobramycin, sisomicin and dioxydin was studied and compared in rats with hematogenic obturation P. aeruginosa pyelonephritis. The drugs were injected intramuscularly in doses of 5, 8, 8 and 50 mg/kg, respectively for 7 days a day after infection. It was shown that on prolongation of the period of the treatment estimation from 24 hours to 7 days after discontinuation of the drug use a significant decrease was observed in the therapeutic efficacy of dioxydin, gentamicin and especially tobramycin. As for sisomicin, the decrease was insignificant. Dioxydin and gentamicin had a similar therapeutic effect at the early and late periods of their estimation after discontinuation of the treatment. They were inferior to tobramycin with respect to the early results and superior to it with respect to the late results. The chemotherapeutic efficacy of sisomycin in both the cases was higher than that of tobramycin, gentamicin and dioxydin.
在患有血源性阻塞性铜绿假单胞菌肾盂肾炎的大鼠中，研究并比较了庆大霉素、妥布霉素、西索米星和多西环素的化疗效果。分别以5、8、8和50mg/kg的剂量肌肉注射这些药物，感染后每天注射一次，共7天。结果表明，在停药后从24小时到7天延长治疗评估期时，观察到多西环素、庆大霉素尤其是妥布霉素的治疗效果显著下降。至于西索米星，下降不明显。停药后早期和晚期评估时，多西环素和庆大霉素具有相似的治疗效果。早期结果方面它们不如妥布霉素，晚期结果方面则优于妥布霉素。在这两种情况下，西索米星的化疗效果均高于妥布霉素、庆大霉素和多西环素。
