Rudzit E A, Lisitsa L I, Zinchenko T A
Farmakol Toksikol. 1978 Mar-Apr;41(2):199-202.
A model of obturation hematogenous pyelonephritis was reproduced in rats by infecting them with Pseudomonas aeruginosa. On the model subject to study was chemotherapeutic activity of dioxidine (50--100 mg/kg per day) as compared to gentamycin (5 mg/kg per day). The drugs were administered intramuscularly for 7 days, starting 24 hours after inoculation of the animals. The action of both dioxidine and gentamycin on lethality, bacteriura, the mass of the kidneys and macroscopic changes in them was approximately the same, but dioxidine extered a greater influence on the seeding rate of the causative agent coming from the kidneys. Both drugs fail to bring about complete recovery of the animals.
通过用铜绿假单胞菌感染大鼠，复制了闭塞性血源性肾盂肾炎模型。在该模型上，研究了二氧嗪（每天50 - 100毫克/千克）与庆大霉素（每天5毫克/千克）相比的化疗活性。在动物接种24小时后开始，将药物肌肉注射7天。二氧嗪和庆大霉素对致死率、菌尿、肾脏质量及其宏观变化的作用大致相同，但二氧嗪对来自肾脏的病原体接种率有更大影响。两种药物均未能使动物完全康复。
