Zinchenko T A, Starkov M V, Rudzit E A, Lisitsa L I
Farmakol Toksikol. 1982 Jan-Feb;45(1):65-70.
Dioxidine (50 mg/kg a day) and carbenicillin (500 mg/kg a day) administered to rats with Ps. aeruginosa hematogenic pyelonephritis for 7 days brought about high therapeutic effect accompanied by bacteremia elimination, noticeable reduction of bacteriuria and dissemination of renal tissue, by improvement of the histological structure of the kidneys as compared with untreated animals. Complete recovery of all the animals (sterilization of the urine and tissue of both the kidneys), and abolition of pyelonephritis signs in the histological structure of the kidneys are attained as a result of combined use of dioxidine and carbenicillin in doses 25 and 250 mg/kg, respectively.
给患有铜绿假单胞菌血源性肾盂肾炎的大鼠每日注射50毫克/千克的二氧嗪和每日注射500毫克/千克的羧苄青霉素，持续7天，产生了很高的治疗效果，伴有菌血症消除、菌尿显著减少以及肾组织扩散，与未治疗的动物相比，肾脏的组织结构得到改善。分别以25毫克/千克和250毫克/千克的剂量联合使用二氧嗪和羧苄青霉素，所有动物实现了完全康复（双侧肾脏尿液和组织无菌），并且在肾脏组织结构中肾盂肾炎体征消失。
