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花生四烯酸环氧化:环氧二十碳三烯酸是大鼠肝脏的内源性成分。

Arachidonic acid epoxidation: epoxyeicosatrienoic acids are endogenous constituents of rat liver.

作者信息

Capdevila J, Pramanik B, Napoli J L, Manna S, Falck J R

出版信息

Arch Biochem Biophys. 1984 Jun;231(2):511-7. doi: 10.1016/0003-9861(84)90415-6.

DOI:10.1016/0003-9861(84)90415-6
PMID:6732246
Abstract

Epoxyeicosatrienoic acids have been isolated and purified from the livers of male rats. They were identified by gas chromatography-mass spectrometric techniques. These results expand the list of in vivo-produced eicosanoids. Their documented in vitro biological activities suggest a role for them in cell and tissue homeostasis.

摘要

环氧二十碳三烯酸已从雄性大鼠肝脏中分离和纯化出来。它们通过气相色谱 - 质谱技术进行鉴定。这些结果扩展了体内产生的类花生酸的种类。它们已被记录的体外生物学活性表明它们在细胞和组织稳态中发挥作用。

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Arachidonic acid epoxidation: epoxyeicosatrienoic acids are endogenous constituents of rat liver.花生四烯酸环氧化:环氧二十碳三烯酸是大鼠肝脏的内源性成分。
Arch Biochem Biophys. 1984 Jun;231(2):511-7. doi: 10.1016/0003-9861(84)90415-6.
2
Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid.花生四烯酸在肝脏细胞色素P-450氧化过程中形成的新型环氧化物。
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Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.花生四烯酸环氧化酶:兔肾中环氧二十碳三烯酸的鉴定
J Lipid Res. 1987 Jul;28(7):840-6.
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Gas chromatographic-mass spectrometric characterisation of some novel hydroxyeicosatetraenoic acids formed on incubation of arachidonic acid with microsomes from induced rat livers.
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Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions.大鼠垂体前叶微粒体组分对花生四烯酸的环氧化作用。
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Metabolism of arachidonic acid by isolated rat hepatocytes, renal cells and by some rabbit tissues. Detection of vicinal diols by mass fragmentography.大鼠离体肝细胞、肾细胞以及一些兔组织中花生四烯酸的代谢。通过质量碎片分析法检测邻二醇。
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Metabolism of arachidonic acid by rat adrenal glomerulosa cells: synthesis of hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids.大鼠肾上腺球状带细胞中花生四烯酸的代谢:羟基二十碳四烯酸和环氧二十碳三烯酸的合成。
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NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols.14,15-环氧二十碳三烯酸依赖烟酰胺腺嘌呤二核苷酸磷酸(NADPH)的微粒体代谢生成双环氧化物和环氧醇。
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Catabolism of epoxy fatty esters by the purified epoxide hydrolase from mouse and human liver.小鼠和人肝脏纯化的环氧水解酶对环氧脂肪酸酯的分解代谢
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Characterization of arachidonic acid metabolites through the 12-lipoxygenase pathway in human epidermis by high-performance liquid chromatography and gas chromatography/mass spectrometry.通过高效液相色谱法和气相色谱/质谱联用技术对人表皮中通过12-脂氧合酶途径产生的花生四烯酸代谢产物进行表征。
Rapid Commun Mass Spectrom. 1995;Spec No:S169-82.

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