Giacchino F, Pozzato M, Piccoli G
Artif Organs. 1984 May;8(2):156-60. doi: 10.1111/j.1525-1594.1984.tb04265.x.
Sera of patients on peritoneal dialysis and regular hemodialysis were analyzed over a follow-up period of 8 months for the capacity of normal lymphocytes to inhibit E-rosette formation. The percentage of inhibition in sera from peritoneal dialysis patients was significantly reduced (p less than 0.02) only 1 month after treatment was started, whereas in hemodialysis patients the percentage of inhibition remained unchanged. No difference was observed between sera collected before and after the hemodialysis sessions. There was no significant positive correlation between the percentage of E-rosette inhibition and p-urea, p-creatinine, s-albumin, and s-proteins, respectively. Statistical analysis of the E-rosette inhibition test by uremic serum and spontaneous E-rosettes in these patients showed a significant regression coefficient (p less than 0.01) in both groups. The fact that, unlike ultrafiltrate from hemodialysis, peritoneal dialysate significantly (p less than 0.05) inhibits the E-rosette formation capacity of normal lymphocytes, confirms these findings, suggesting an inhibitory activity of serum factors on lymphocyte function.
在8个月的随访期内，对接受腹膜透析和常规血液透析的患者血清进行分析，以检测正常淋巴细胞抑制E玫瑰花结形成的能力。腹膜透析患者血清中的抑制百分比仅在开始治疗1个月后就显著降低（p<0.02），而血液透析患者的抑制百分比保持不变。血液透析前后采集的血清之间未观察到差异。E玫瑰花结抑制百分比与血尿素、血肌酐、血清白蛋白和血清蛋白之间分别无显著正相关。对这些患者的尿毒症血清和自发E玫瑰花结进行的E玫瑰花结抑制试验的统计分析显示，两组的回归系数均具有显著性（p<0.01）。与血液透析超滤物不同，腹膜透析液能显著（p<0.05）抑制正常淋巴细胞的E玫瑰花结形成能力，这一事实证实了这些发现，表明血清因子对淋巴细胞功能具有抑制活性。
