Nielsen D W, Franseen L, Fowler D
Audiology. 1984;23(3):297-308. doi: 10.3109/00206098409072841.
6 squirrel monkeys (Saimiri scuireus ) were exposed to an octave band of noise with a center frequency of 500 Hz under both continuous and interrupted conditions. Continuous exposures lasted for 4, 8, 16, 24, 48, 72 and 96 h, with complete recovery of hearing before the next exposure. The interrupted exposure was 96 h, long with 5-min interruptions so that temporary threshold shift (TTS) could be measured at 2, 4, 8, 12, 16, 24, 36, 48, 60, 72 and 84 h of exposure. There were no differences in TTS from 8 to 96 h of exposure between the two conditions. However, at 4 h of exposure, the interrupted exposure showed significantly less TTS (p less than 0.05) than the continuous exposure. The only difference between the exposures was a 5-min interruption at 2 h of exposure during the interrupted exposure. Thus, the interrupted-exposure method is valid for making generalizations about continuous exposures of 8 h or longer. The results also confirmed our previous finding that there was no asymptotic threshold shift for the squirrel monkey although we extended the exposure time to 96 h in this experiment. The similarity of human and squirrel monkey TTS growth functions is consistent with our earlier results and supports the suitability of the squirrel monkey as an animal model for noise-induced hearing loss in humans.
6只松鼠猴（松鼠猴属）在连续和间断条件下暴露于中心频率为500赫兹的一个倍频程噪声中。连续暴露持续4、8、16、24、48、72和96小时，在下一次暴露前听力完全恢复。间断暴露为96小时，长时间伴有5分钟的中断，以便在暴露2、4、8、12、16、24、36、48、60、72和84小时时测量暂时性阈移（TTS）。在两种条件下，暴露8至96小时的TTS没有差异。然而，在暴露4小时时，间断暴露的TTS明显低于连续暴露（p小于0.05）。两种暴露之间的唯一差异是在间断暴露的暴露2小时时有5分钟的中断。因此，间断暴露方法对于推断8小时或更长时间的连续暴露是有效的。结果还证实了我们之前的发现，即尽管在本实验中我们将暴露时间延长至96小时，但松鼠猴没有渐近性阈移。人类和松鼠猴TTS增长函数的相似性与我们早期的结果一致，并支持松鼠猴作为人类噪声性听力损失动物模型的适用性。
