Amenta F, Cantagalli A, Cavallotti C, Mione M C, Sancesario G
Basic Res Cardiol. 1984 Jan-Feb;79(1):80-5. doi: 10.1007/BF01935810.
The topographic distribution of (3H)-spiroperidol binding sites (corresponding to dopamine receptors likely) was studied in rabbit splenic artery by the use of a histoautoradiographic technique. (3H)-spiroperidol was localized preferentially at the level of smooth muscle cells of the media as well as in close relation with cellular membrane of endothelial cells. The findings of a constant distribution of (3H)-spiroperidol binding sites within the medial layer of the splenic artery led us to hypothesize that these receptors mediate the relaxation of the splenic artery determined by dopamine infusion.
运用组织放射自显影技术，研究了（3H）-螺哌啶醇结合位点（可能对应多巴胺受体）在兔脾动脉中的拓扑分布。（3H）-螺哌啶醇优先定位于中膜平滑肌细胞水平以及与内皮细胞膜密切相关的位置。脾动脉中膜层内（3H）-螺哌啶醇结合位点分布恒定的研究结果使我们推测，这些受体介导了多巴胺输注所引起的脾动脉舒张。
