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Formation of 19-nor-10-keto-25-hydroxyvitamin D3 in cultured mammalian cells.

作者信息

Lester G E, Horst R L, Napoli J L

出版信息

Biochem Biophys Res Commun. 1984 May 16;120(3):919-25. doi: 10.1016/s0006-291x(84)80194-1.

DOI:10.1016/s0006-291x(84)80194-1
PMID:6732791
Abstract

Cultured dog kidney cells convert 25-hydroxyvitamin D3 into more polar metabolites during in vitro incubations. One elutes with 1,25-dihydroxyvitamin D3 from high pressure liquid chromatographic silica columns with hexane:isopropanol (9:1), but can be separated from 1,25-dihydroxyvitamin D3 by elution with dichloromethane:isopropanol (95:5). This peak has been isolated, purified and identified by mass spectral analysis to be 19-nor-10-keto-25-hydroxyvitamin D3.

摘要

相似文献

1
Formation of 19-nor-10-keto-25-hydroxyvitamin D3 in cultured mammalian cells.
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2
Phagocytic cells synthesize 19-nor-10-keto-25-hydroxyvitamin D3, a metabolite that may induce differentiation of the human monoblastic cell line U937.吞噬细胞合成19-去甲-10-酮-25-羟基维生素D3，这是一种可能诱导人单核细胞系U937分化的代谢产物。
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3
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4
Metabolism of 25-hydroxyvitamin D3 by rat kidney cells in culture: isolation and identification of cis- and trans-19-nor-10-oxo-25-hydroxyvitamin D3.培养的大鼠肾细胞对25-羟基维生素D3的代谢：顺式和反式-19-去甲-10-氧代-25-羟基维生素D3的分离与鉴定
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Chromatographic separation of 24(R),25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3-26,23-lactone using a cyano-bonded phase packing.使用氰基键合相填料对24(R),25-二羟基维生素D3和25-羟基维生素D3-26,23-内酯进行色谱分离。
J Chromatogr. 1983 Aug 12;276(1):69-75.
6
23,24,25-Trihydroxyvitamin D3, 24,25,26-trihydroxyvitamin D3, 24-keto-25-hydroxyvitamin D3, and 23-dehydro-25-hydroxyvitamin D3: new in vivo metabolites of vitamin D3.23,24,25-三羟基维生素D3、24,25,26-三羟基维生素D3、24-酮-25-羟基维生素D3和23-脱氢-25-羟基维生素D3：维生素D3新的体内代谢产物。
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23,25-Dihydroxyvitamin D3: a natural precursor in the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone.23,25-二羟基维生素D3：25-羟基维生素D3-26,23-内酯生物合成中的天然前体。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4805-8. doi: 10.1073/pnas.78.8.4805.
8
Synthesis of 25-hydroxyvitamin D3-26,23-lactone but not 24,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3 in opossum kidney cells treated with 1 alpha, 25-dihydroxyvitamin D3.在经1α,25 - 二羟基维生素D3处理的负鼠肾细胞中，由25 - 羟基维生素D3合成25 - 羟基维生素D3 - 26,23 - 内酯而非24,25 - 二羟基维生素D3 。
Horm Metab Res. 1995 Feb;27(2):83-9. doi: 10.1055/s-2007-979914.
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10-Keto or 25-hydroxy substitution confer equivalent in vitro bone-resorbing activity to vitamin D3.
Arch Biochem Biophys. 1985 Feb 1;236(2):555-8. doi: 10.1016/0003-9861(85)90658-7.
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19-nor-10-ketovitamin D derivatives: unique metabolites of vitamin D3, vitamin D2, and 25-hydroxyvitamin D3.19-去甲-10-酮维生素D衍生物：维生素D3、维生素D2和25-羟基维生素D3的独特代谢产物。
Biochemistry. 1983 Jul 19;22(15):3636-40. doi: 10.1021/bi00284a015.

引用本文的文献

1
Effects of prostaglandin E2 and indomethacin on 25-hydroxyvitamin D3-1 alpha-hydroxylase activity in isolated kidney cells of normal and streptozotocin-induced diabetic rats.前列腺素E2和吲哚美辛对正常及链脲佐菌素诱导的糖尿病大鼠离体肾细胞中25-羟基维生素D3-1α-羟化酶活性的影响
Calcif Tissue Int. 1985 Dec;37(6):625-9. doi: 10.1007/BF02554920.
2
Phagocytic cells synthesize 19-nor-10-keto-25-hydroxyvitamin D3, a metabolite that may induce differentiation of the human monoblastic cell line U937.吞噬细胞合成19-去甲-10-酮-25-羟基维生素D3，这是一种可能诱导人单核细胞系U937分化的代谢产物。
Proc Natl Acad Sci U S A. 1985 Dec;82(23):8218-21. doi: 10.1073/pnas.82.23.8218.
3
25-Hydroxyvitamin D3 metabolism in a human leukemia cell line.
人白血病细胞系中25-羟基维生素D3的代谢
Calcif Tissue Int. 1986 Nov;39(5):328-33. doi: 10.1007/BF02555200.
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Production of 1,25-dihydroxyvitamin D3 by human T cell lymphotrophic virus-I-transformed lymphocytes.人嗜T细胞病毒-I转化淋巴细胞产生1,25-二羟基维生素D3
J Clin Invest. 1986 Aug;78(2):592-6. doi: 10.1172/JCI112614.