Simon S A, McIntosh T J
Biochim Biophys Acta. 1984 Jun 13;773(1):169-72. doi: 10.1016/0005-2736(84)90562-5.
It has been shown recently by Rowe ((1983) Biochemistry 22, 3299-3305) that ethanol has a 'biphasic' effect on the transition temperature (Tm) of phosphatidylcholine bilayers, reducing Tm at low concentrations but increasing Tm at high concentrations. Our X-ray diffraction data show that this reversal of Tm is a consequence of the induction of an unusual gel phase, where the lipid hydrocarbon chains from apposing monolayers fully interpenetrate or interdigitate. The properties of this interdigitated phase also explain the lipid chain length dependence of the reversal in the Tm versus ethanol concentration curves and the narrow width of the transition at high ethanol concentrations, as well as spectroscopic and calorimetric data from lipid suspensions containing other drugs such as methanol, benzyl alcohol, phenyl ethanol, and chlorpromazine.
罗（(1983)《生物化学》22卷，3299 - 3305页）最近表明，乙醇对磷脂酰胆碱双层膜的转变温度（Tm）具有“双相”效应，在低浓度时降低Tm，但在高浓度时升高Tm。我们的X射线衍射数据表明，Tm的这种反转是诱导出一种异常凝胶相的结果，在该相中，来自相对单层的脂质烃链完全相互渗透或交叉。这种交叉相的性质还解释了Tm与乙醇浓度曲线反转的脂质链长度依赖性以及高乙醇浓度下转变的窄宽度，以及来自含有其他药物（如甲醇、苯甲醇、苯乙醇和氯丙嗪）的脂质悬浮液的光谱和量热数据。
