Erickson W D, Yellin A M, Hopwood J H, Realmuto G M, Greenberg L M
Biol Psychiatry. 1984 May;19(5):745-53.
In contrast to studies of adult psychiatric patients, there was no striking difference between vigilance task performance by 11 newly diagnosed, previously untreated adolescent schizophrenics and that of 58 nonpsychotic adolescent comparison subjects. Neuroleptic treatment failed to improve the performance of the schizophrenic subjects. Sedation, a frequent side effect, was associated with significant prolongation of reaction time and an increase in error rate. Attentional characteristics of adolescent schizophrenics appear to resemble those of other disturbed children. Their response to neuroleptics appears to be limited and the deleterious effects of sedation on attention may well outweigh any clinical benefit attributable to sedation. Findings are discussed in terms of methodology and age-related characteristics.
与针对成年精神病患者的研究不同，11名新诊断出的、此前未接受过治疗的青少年精神分裂症患者在警觉任务表现上与58名非精神病性青少年对照受试者之间没有显著差异。抗精神病药物治疗未能改善精神分裂症患者的表现。镇静作为一种常见的副作用，与反应时间显著延长和错误率增加有关。青少年精神分裂症患者的注意力特征似乎与其他受困扰儿童的相似。他们对抗精神病药物的反应似乎有限，而且镇静对注意力的有害影响很可能超过镇静带来的任何临床益处。从方法学和与年龄相关的特征方面对研究结果进行了讨论。
