Mavroidis M L, Kanter D R, Hirschowitz J, Garver D L
J Clin Psychopharmacol. 1984 Jun;4(3):155-7.
The authors examined plasma levels of thiothixene and clinical response in 19 DSM-III diagnosed inpatient schizophrenics, using an improved methodology. A significant curvilinear correlation was demonstrated between clinical response and plasma levels for thiothixene (p less than 0.02). Optimal clinical response to thiothixene appears to be associated with plasma levels from 2.0 to 15.0 ng/ml (p less than 0.05). These findings suggest that laboratory measurement of thiothixene levels may assist in determining the minimum effective dose for individual patients.
作者采用一种改进的方法，对19名经《精神疾病诊断与统计手册》第三版（DSM-III）诊断的住院精神分裂症患者的硫利达嗪血浆水平及临床反应进行了研究。结果显示，硫利达嗪的临床反应与血浆水平之间存在显著的曲线相关性（p<0.02）。硫利达嗪的最佳临床反应似乎与2.0至15.0 ng/ml的血浆水平相关（p<0.05）。这些发现表明，硫利达嗪水平的实验室检测可能有助于确定个体患者的最低有效剂量。
