Levin E D, Gunne L M
Department of Psychology, University of California, Los Angeles 90024.
Psychopharmacology (Berl). 1989;97(4):496-500. doi: 10.1007/BF00439554.
Cebus apella monkeys were chronically administered the antipsychotic drug fluphenazine decanoate for periods ranging from 3.5 to 5.5 years. In the present study, four of these monkeys and two controls were tested for cognitive abilities on a spatial learning task, which consisted of an original discrimination and four reversals of that discrimination. No effect of fluphenazine administration was seen in the rate of learning the original discrimination, but the carryover of learning across discrimination reversals was significantly reduced by fluphenazine. After overtraining on the original discrimination, the controls showed the normal difficulty in learning the first reversal. The fluphenazine-treated monkeys showed no such disruption. On subsequent reversals, the controls showed continually improving performance, so that on the third and fourth reversals they had near-perfect scores. On the other hand, the fluphenazine-treated monkeys showed no change over the four reversals. Unlike normal monkeys, their learning did not improve with practice. Although simple forms of learning seem to be relatively unaffected by chronic fluphenazine administration, more complex learning is disrupted.
对松鼠猴长期施用抗精神病药物癸酸氟奋乃静，施用时长在3.5年至5.5年之间。在本研究中，对其中4只猴子和2只对照猴进行了一项空间学习任务的认知能力测试，该任务包括一次初始辨别以及该辨别的四次反转。在学习初始辨别时，未观察到施用氟奋乃静对学习速度有影响，但氟奋乃静显著降低了跨辨别反转的学习迁移。在对初始辨别进行过度训练后，对照猴在学习第一次反转时表现出正常难度。经氟奋乃静处理的猴子未出现此类干扰。在后续反转中，对照猴的表现持续改善，以至于在第三次和第四次反转时它们获得了近乎完美的分数。另一方面，经氟奋乃静处理的猴子在四次反转中没有变化。与正常猴子不同，它们的学习并未因练习而改善。尽管简单形式的学习似乎相对不受长期施用氟奋乃静的影响，但更复杂的学习却受到了干扰。
