Dougherty J H, Levy D E, Weksler B B
Lancet. 1977 Apr 16;1(8016):821-4. doi: 10.1016/s0140-6736(77)92774-x.
Circulating platelet aggregates formed in vivo were serially measured, and platelet-aggregation thresholds were determined in vitro in 82 patients with acute cerebral ischaemia. The percentage of aggregated platelets was increased in 53 patients with completed stroke (30.9% +/- 2.0) and in 29 patients with transient ischaemic attacks (34.1% +/- 2.3), all studied within 10 days of the acute event. These values were higher (P less than 0.001) than levels of aggregated platelets in 30 patients with non-vascular neurological disease (16.8% +/- 2.3). The percentage of aggregated platelets returned to normal 10 days to 6 wk after acute cerebral ischaemia. Aspirin and dipyridamole did not affect either the increase in or subsequent normalisation of circulating-platelet-aggregate levels in these patients. Platelet-aggregation sensitivity to adenosine diphosphate and adrenaline was also increased in patients with acute cerebral ischaemia, but this abnormally resolved during convalescence. Platelet activation is abnormal in acute cerebral ischaemia but usually returns to normal with or without anti-platelet therapy. This activation of platelets may contribute to the clinical manifestations of occlusive vascular disease.
对体内形成的循环血小板聚集体进行了连续测量，并在82例急性脑缺血患者中体外测定了血小板聚集阈值。在急性事件发生10天内对53例完全性卒中患者（30.9%±2.0）和29例短暂性脑缺血发作患者（34.1%±2.3）进行研究，结果显示聚集血小板的百分比增加。这些值高于30例非血管性神经疾病患者（16.8%±2.3）的聚集血小板水平（P<0.001）。急性脑缺血后10天至6周，聚集血小板的百分比恢复正常。阿司匹林和双嘧达莫对这些患者循环血小板聚集体水平的升高或随后的正常化均无影响。急性脑缺血患者对二磷酸腺苷和肾上腺素的血小板聚集敏感性也增加，但这种异常在恢复期消失。急性脑缺血时血小板激活异常，但无论是否进行抗血小板治疗，通常都会恢复正常。血小板的这种激活可能导致闭塞性血管疾病的临床表现。
