Capitani S, Cocco L, Matteucci A, Caramelli E, Papa S, Manzoli F A
Cell Biol Int Rep. 1984 Apr;8(4):289-96. doi: 10.1016/0309-1651(84)90155-3.
Phospholipid liposomes affect the histone pattern of isolated rat liver nuclei. Multilamellar vesicles (MLV) obtained with phosphatidylserine (PS) release a large amount of the lysine rich histones, while those obtained with phosphatidylcholine (PC) do not induce significant changes with respect to controls. This different response has been compared to the effects obtained with Heparin, which slightly modifies the relative ratio of the histone fractions. These data might account for the mode by which phospholipids induce transitions of the chromatin structure and changes of the endogenous RNA polymerase activity.
磷脂脂质体影响分离的大鼠肝细胞核的组蛋白模式。用磷脂酰丝氨酸（PS）获得的多层囊泡（MLV）释放出大量富含赖氨酸的组蛋白，而用磷脂酰胆碱（PC）获得的多层囊泡与对照组相比未引起显著变化。已将这种不同的反应与肝素所产生的效应进行了比较，肝素会轻微改变组蛋白组分的相对比例。这些数据可能解释了磷脂诱导染色质结构转变和内源性RNA聚合酶活性变化的方式。
