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母亲在受孕前使用口服避孕药的儿童的长期随访。

Long-term follow-up of children whose mothers used oral contraceptives prior to conception.

作者信息

Magidor S, Palti H, Harlap S, Baras M

出版信息

Contraception. 1984 Mar;29(3):203-14. doi: 10.1016/s0010-7824(84)80001-3.

Abstract

Anthropometric, psychometric and hematologic measurements were made at intervals in the first 3 years of life in a cohort of 732 infants, including 177 (24.2%) whose mothers used oral contraceptives (OC) prior to conception. Analysis of the data focused on weight and height measurements at 3, 9, 12, 24 and 36 months of age; hemoglobin and hematocrit at 9 months; development quotient (DQ) at 2 years and its components, posture, coordination, language and social; and intelligence quotient (IQ) at 3 years and its verbal and nonverbal components. Analyses were made for both sexes combined and males and females separately, by examining crude means, and means adjusted through linear multiple regression for birthweight, age of child at the time of examination, height of mother, mother's weight-for-height centile, birth-order, maternal and paternal education, and maternal smoking. No significant differences were found between the children whose mothers did or did not use oral contraceptives.

摘要

对732名婴儿组成的队列在其生命的前3年定期进行人体测量、心理测量和血液学测量,其中177名(24.2%)婴儿的母亲在受孕前使用过口服避孕药(OC)。数据分析集中于3、9、12、24和36月龄时的体重和身高测量;9月龄时的血红蛋白和血细胞比容;2岁时的发育商(DQ)及其组成部分,即姿势、协调能力、语言能力和社交能力;以及3岁时的智商(IQ)及其语言和非语言组成部分。通过检查原始均值以及经线性多元回归调整后的均值(调整因素包括出生体重、检查时孩子的年龄、母亲身高、母亲身高体重百分位数、出生顺序、父母教育程度以及母亲吸烟情况),对男女合并以及男性和女性分别进行了分析。未发现母亲使用或未使用口服避孕药的孩子之间存在显著差异。

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