Genetic analysis of the relationships between ischaemic heart disease and the blood lipid level.

The results of clinical-experimental research on the prevalence of ischaemic heart disease (IHD), the cholesterol (CS) and triglyceride (TG) level in a random sample of the male population of the city of Andizhan in the Uzbek SSR, aged 40-59 years (n = 593) have shown the following correlations between the mentioned variables: IHD - CS: rp = 0.61, IHD - TG: 0.64, CS - TG: 0.28. These findings suggest the existence of certain factors - genetic and/or environmental ones - common to the mentioned pairs of traits. Genetic analysis of the structure of common elements for IHD, CS and TG has shown that the genetic component of IHD liability is determined by genetic factors of the CS (50.2% and the TG level (47.3%). As regards the influence of environmental factors on IHD risk, statistical analysis has not so far permitted to draw any reliable conclusions.