Schneider E, Fischer P A, Clemens R, Balzereit F, Fünfgeld E W, Haase H J
Dtsch Med Wochenschr. 1984 Jun 22;109(25):987-90. doi: 10.1055/s-2008-1069311.
The effectiveness of memantine on the symptoms of Parkinson's disease was investigated in 67 patients (39 males, 28 females) mostly between 55 and 75 years. The study was multi-center placebo-controlled with four treatment groups, i. e. patients with and without pre- and after-treatment with other anti-Parkinson medication receiving either placebo or memantine as sole or additional medication. The analysis of 61 evaluable cases showed a positive statistically significant influence on the single symptom tremor as well as on the neurological overall symptomatology (Webster-scale total score). Despite the inadequately ascertained mode of action memantine promises success particularly in milder and initial forms of the Parkinson syndrome either used as monotherapy or as an adjuvant.
对67例患者（39例男性，28例女性）进行了美金刚对帕金森病症状有效性的研究，这些患者年龄大多在55至75岁之间。该研究为多中心安慰剂对照研究，分为四个治疗组，即无论是否在治疗前后使用其他抗帕金森药物的患者，分别接受安慰剂或美金刚作为单一药物或附加药物治疗。对61例可评估病例的分析显示，美金刚对单一症状震颤以及神经学总体症状（韦伯斯特量表总分）有积极的统计学显著影响。尽管美金刚的作用方式尚未完全明确，但它有望取得成功，尤其在较轻和初始形式的帕金森综合征中，无论是作为单一疗法还是辅助疗法。
