口服避孕药类固醇导致年轻女性体内咖啡因停留时间迅速增加。
Rapid onset of an increase in caffeine residence time in young women due to oral contraceptive steroids.
作者信息
Rietveld E C, Broekman M M, Houben J J, Eskes T K, van Rossum J M
出版信息
Eur J Clin Pharmacol. 1984;26(3):371-3. doi: 10.1007/BF00548769.
PMID:6734698
Abstract
Oral contraceptive steroids increased the residence time of caffeine in 9 young women by a factor of 2. The effect was already manifested during the first cycle 2 weeks after starting oral contraceptive steroids (OCS) and was slightly increased in the second cycle, after 6 weeks on OCS. Toxic effects attributed to oral contraceptive steroids may in part be indirect and due to prolonged retention of absorbed toxic agents to which women are exposed.
摘要
口服避孕类固醇使9名年轻女性体内咖啡因的停留时间增加了一倍。在开始服用口服避孕类固醇（OCS）两周后的第一个周期内，这种效果就已显现，在服用OCS六周后的第二个周期，效果略有增强。归因于口服避孕类固醇的毒性作用可能部分是间接的，并且是由于女性接触的吸收性有毒物质的滞留时间延长所致。
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