Edmonds C J, Smith T, Griffiths R D, Mackenzie J, Edwards R H
Clin Sci (Lond). 1985 Apr;68(4):379-85. doi: 10.1042/cs0680379.
Total body potassium (40K method) and total body water and exchangeable sodium (both by isotope dilution) were determined in 26 boys, aged 5-17 years, with muscular dystrophy. Total body potassium values were compared with measurements in a large series of normal boys on the basis of height. Total body potassium was reduced even in the youngest patients and was only slightly higher in the older boys, despite their considerably greater height. Exchangeable sodium increased with increasing height in a way similar to that of normal boys. Total body water was also reduced but increased with growth, although to a lesser extent than expected for normal boys. The total body water measurements indicated that many of the affected boys were very obese, despite an apparently normal body weight. An intravenous bolus of 22Na distributed at a similar rate in boys with muscular dystrophy to that in normal males. In relation to the predicted values, total body potassium and 24 h urinary creatinine excretion of the affected boys both declined at a rate of 4% per year.
对26名年龄在5至17岁的患肌肉萎缩症男孩测定了总体钾（40K法）、总体水以及可交换钠（均采用同位素稀释法）。根据身高，将总体钾值与一大组正常男孩的测量值进行比较。即使是最年幼的患者，总体钾也降低，而年龄较大的男孩尽管身高显著更高，但总体钾仅略高一点。可交换钠随身高增加的方式与正常男孩相似。总体水也减少，但随生长而增加，不过增加程度低于正常男孩预期。总体水测量结果表明，许多患病男孩尽管体重看似正常，但却非常肥胖。静脉推注22Na后，其在患肌肉萎缩症男孩体内的分布速率与正常男性相似。与预测值相比，患病男孩的总体钾和24小时尿肌酐排泄量均以每年4%的速率下降。
