Naito Y, Okuda K, Takazoe I
Infect Immun. 1984 Jul;45(1):47-51. doi: 10.1128/iai.45.1.47-51.1984.
Serum and gingival crevicular fluid from normal healthy adults and patients with periodontitis were screened for immunoglobulin G antibodies to antigens from Bacteroides gingivalis 381, Bacteroides intermedius 24, Bacteroides loescheii ATCC 15930, Fusobacterium nucleatum ATCC 25586, Eikenella corrodens 1073, Actinobacillus actinomycetemcomitans ATCC 29522, and Capnocytophaga sp. strain M-12. Immunoglobulin G antibody titers to the antigens were measured by an enzyme-linked immunosorbent assay. The antibody levels to B. gingivalis in serum and gingival crevicular fluid were significantly higher in the samples from patients with periodontitis than in samples from healthy individuals. Although there were individual differences within patient groups, a positive correlation (P less than 0.01) was found between the serum immunoglobulin G levels to B. gingivalis and the development of periodontitis. The antibodies to F. nucleatum (P less than 0.05), E. corrodens (P less than 0.05), and A. actinomycetemcomitans were slightly higher in patients with periodontitis than in normal subjects. There were no remarkable differences between the two groups in titers to B. intermedius, B. loescheii, and Capnocytophaga sp.
对正常健康成年人以及牙周炎患者的血清和龈沟液进行筛查，检测其中针对牙龈拟杆菌381、中间普氏菌24、洛氏普氏菌ATCC 15930、具核梭杆菌ATCC 25586、腐蚀艾肯菌1073、伴放线放线杆菌ATCC 29522和嗜二氧化碳噬纤维菌M-12菌株抗原的免疫球蛋白G抗体。通过酶联免疫吸附测定法测量针对这些抗原的免疫球蛋白G抗体滴度。牙周炎患者样本中血清和龈沟液中针对牙龈拟杆菌的抗体水平显著高于健康个体样本中的水平。虽然患者组内存在个体差异，但发现血清中针对牙龈拟杆菌的免疫球蛋白G水平与牙周炎的发展之间存在正相关（P小于0.01）。牙周炎患者中针对具核梭杆菌（P小于0.05）、腐蚀艾肯菌（P小于0.05）和伴放线放线杆菌的抗体略高于正常受试者。两组在针对中间普氏菌、洛氏普氏菌和嗜二氧化碳噬纤维菌的滴度方面没有显著差异。
