Macaione S, Di Giorgio R M, Nicotina P A, Ientile R
J Neurochem. 1984 Aug;43(2):303-15. doi: 10.1111/j.1471-4159.1984.tb00901.x.
The effects of subcutaneous daily treatment with thyroxine on cell proliferation, differentiation, polyamines, and gamma-aminobutyric acid metabolism in the rat retina were studied during the first 20 postnatal days. The retinal layers of the treated rats displayed an enhanced cell differentiation which reached its maximum 9-12 days from birth; but this effect stopped very quickly and was finished by the 20th postnatal day. Primarily there was an increase in ornithine decarboxylase activity which was accompanied by an increase in putrescine, spermidine, and spermine levels. S-Adenosylmethionine decarboxylase was induced later than ODC; corresponding with the enhanced synaptogenesis, glutamate decarboxylase increased 15-fold between the fourth and 15th days. Our data are consistent with the hypothesis that thyroxine may exert some of its effects by inducing the enzymes which regulate polyamine metabolism and synaptogenesis.
在出生后的前20天内，研究了每日皮下注射甲状腺素对大鼠视网膜细胞增殖、分化、多胺和γ-氨基丁酸代谢的影响。接受治疗的大鼠视网膜层细胞分化增强，在出生后9至12天达到最大值；但这种作用很快停止，并在出生后第20天结束。首先是鸟氨酸脱羧酶活性增加，同时腐胺、亚精胺和精胺水平也增加。S-腺苷甲硫氨酸脱羧酶的诱导晚于鸟氨酸脱羧酶；与突触形成增强相一致，谷氨酸脱羧酶在第4天至第15天之间增加了15倍。我们的数据与以下假设一致，即甲状腺素可能通过诱导调节多胺代谢和突触形成的酶来发挥其部分作用。
