Han Wentao, Li Haoyu, Chen Baihua
Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
Hunan Clinical Research Center of Ophthalmic Disease, Changsha 410011, China.
Pharmaceutics. 2022 Jul 19;14(7):1500. doi: 10.3390/pharmaceutics14071500.
Spermidine, a natural polyamine, exists in almost all human tissues, exhibiting broad properties like anti-aging, autophagy induction, anti-inflammation, anti-oxidation, cell proliferation activation, and ion channel regulation. Considering that spermidine is already present in human nutrition, recent studies targeting supplementing exogenous sources of this polyamine appear feasible. The protective role of spermidine in various systems has been illuminated in the literature, while recent progress of spermidine administration in ocular diseases remains to be clarified. This study shows the current landscape of studies on spermidine and its potential to become a promising therapeutic agent to treat ocular diseases: glaucoma, optic nerve injury, age-related macular degeneration (AMD), cataracts, dry eye syndrome, and bacterial keratitis. It also has the potential to become a potent biomarker to predict keratoconus (KC), cataracts, uveitis, glaucoma, proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and retinopathy of prematurity (ROP). We also summarize the routes of administration and the effects of spermidine at different doses.
亚精胺是一种天然多胺，存在于几乎所有人体组织中，具有广泛的特性，如抗衰老、诱导自噬、抗炎、抗氧化、激活细胞增殖和调节离子通道。鉴于人体营养中已存在亚精胺，近期针对补充这种多胺外源来源的研究似乎是可行的。亚精胺在各种系统中的保护作用已在文献中得到阐明，而亚精胺在眼部疾病治疗中的最新进展仍有待明确。本研究展示了亚精胺研究的现状及其成为治疗眼部疾病（青光眼、视神经损伤、年龄相关性黄斑变性（AMD）、白内障、干眼综合征和细菌性角膜炎）的有前景治疗药物的潜力。它还有潜力成为预测圆锥角膜（KC）、白内障、葡萄膜炎、青光眼、增殖性糖尿病视网膜病变（PDR）、增殖性玻璃体视网膜病变（PVR）和早产儿视网膜病变（ROP）的有效生物标志物。我们还总结了亚精胺的给药途径和不同剂量的作用。
