麦角新碱诱导的动脉扩张：一种内皮介导的效应。

Ergometrine-induced arterial dilatation: an endothelium-mediated effect.

作者信息

Griffith T M, Edwards D H, Lewis M J, Henderson A H

出版信息

J Mol Cell Cardiol. 1984 May;16(5):479-82. doi: 10.1016/s0022-2828(84)80619-7.

Abstract

Ergometrine has generally been regarded as a vasoconstrictor and is used clinically to provoke coronary vasospasm in susceptible patients [3, 8, 9]. The ergometrine response appears however to be complex in that it can be biphasic, the constrictor response being preceded by an initial dilator response in experimental models [4]. The explanation for this is unknown, as is the underlying mechanism responsible for the clinical condition of coronary vasospasm. We have investigated this biphasic response in isolated artery preparations and shown that the dilator component is due to ergometrine-induced release of endothelium-derived relaxant factor (EDRF).

摘要

麦角新碱通常被视为一种血管收缩剂，临床上用于诱发易感患者的冠状动脉痉挛[3, 8, 9]。然而，麦角新碱的反应似乎很复杂，因为在实验模型中它可能是双相的，收缩反应之前会有一个初始的舒张反应[4]。对此的解释尚不清楚，导致冠状动脉痉挛临床状况的潜在机制也不清楚。我们在离体动脉制剂中研究了这种双相反应，并表明舒张成分是由于麦角新碱诱导的内皮源性舒张因子（EDRF）释放所致。