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巴氯芬撤药后癫痫持续状态。

Status epilepticus after baclofen withdrawal.

作者信息

Hyser C L, Drake M E

出版信息

J Natl Med Assoc. 1984 May;76(5):533, 537-8.

PMID:6737510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2561766/
Abstract

Baclofen is widely used in the treatment of spasticity of spinal origin. It is relatively free of side effects or toxic actions on the nervous system or other organs. Agitation, personality change, and auditory and visual hallucinations have been described following its abrupt withdrawal. One patient with generalized seizures and one with complex partial seizures after baclofen withdrawal have been reported. This paper presents a patient who developed status epilepticus after baclofen withdrawal, and who sustained hypoxic cerebral injury. This observation further emphasizes the possibility of infrequent complications of baclofen therapy, and the advisability of gradual changes in baclofen dosage.

摘要

巴氯芬广泛用于治疗脊髓源性痉挛。它对神经系统或其他器官相对没有副作用或毒性作用。已有报道称，突然停药后会出现激动、人格改变以及听觉和视觉幻觉。曾有1例全身强直阵挛性发作和1例停药后复杂性部分性发作的病例报告。本文介绍1例巴氯芬停药后发生癫痫持续状态并伴有缺氧性脑损伤的患者。这一观察结果进一步强调了巴氯芬治疗罕见并发症的可能性，以及逐渐改变巴氯芬剂量的可取性。

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本文引用的文献

1
Baclofen as an anticonvulsant in experimental models of convulsions.巴氯芬在惊厥实验模型中作为一种抗惊厥药。
Exp Neurol. 1981 May;72(2):346-51. doi: 10.1016/0014-4886(81)90228-4.
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Complications of baclofen withdrawal.巴氯芬戒断的并发症。
Arch Neurol. 1981 Sep;38(9):588-9. doi: 10.1001/archneur.1981.00510090082011.
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Clinical and experimental aspects of barbiturate withdrawal convulsions.巴比妥类药物戒断性惊厥的临床与实验研究
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Baclofen in spasticity.
Lancet. 1977 Sep 17;2(8038):594-5.
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Hallucinations after withdrawal of baclofen.巴氯芬戒断后的幻觉。
Lancet. 1977 Apr 16;1(8016):858. doi: 10.1016/s0140-6736(77)92809-4.

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