Arzate M E, Ponce H, Pasantes-Morales H
J Neurosci Res. 1984;11(3):271-80. doi: 10.1002/jnr.490110307.
The effects of 4-aminopyridine (4-AP) and of taurine on the guinea pig ileum were examined. Four-AP increases the basal activity from 1.3 to 6.45 cm2/min. This effect is atropine-sensitive and calcium-dependent. Taurine counteracts the effects of 4-AP on muscle contracture in a concentration-dependent manner. In muscles preincubated with 20 mM taurine, the effect of 4-AP decreased about 65%. Taurine added at the time of maximal effect of 4-AP reduced the muscle contracture induced by the drug to the basal levels. Glycine and beta-alanine did not influence the contracture induced by 4-AP, whereas 25 mM gamma-aminobutyric acid (GABA) reduced it by 30%. Taurine reduced the basal muscle activity by 50% but did not affect the contracture induced by exogenously applied acetylcholine.
研究了4-氨基吡啶（4-AP）和牛磺酸对豚鼠回肠的作用。4-AP使基础活性从1.3增加到6.45平方厘米/分钟。这种作用对阿托品敏感且依赖于钙。牛磺酸以浓度依赖的方式抵消4-AP对肌肉挛缩的作用。在预先用20 mM牛磺酸孵育的肌肉中，4-AP的作用降低了约65%。在4-AP达到最大作用时加入牛磺酸，可将该药物诱导的肌肉挛缩降低至基础水平。甘氨酸和β-丙氨酸不影响4-AP诱导的挛缩，而25 mMγ-氨基丁酸（GABA）可使其降低30%。牛磺酸使基础肌肉活性降低50%，但不影响外源性应用乙酰胆碱诱导的挛缩。
