Buge A, Supino-Viterbo V, Rancurel G, Pontes C
J Neurol Neurosurg Psychiatry. 1981 Jan;44(1):62-7. doi: 10.1136/jnnp.44.1.62.
Seventy patients admitted to hospital with bismuth encephalopathy had repeated clinical and EEG examinations. All the patients exhibited myoclonic jerks, but no paroxysmal features ever appeared on EEG. Computed tomography showed cortical hyperdensities. Seizures were observed in 22 patients, but epileptic EEG patterns appeared only when the bismuth blood level was below 1500 microgram/1. It is suggested that a high cortical intracellular bismuth concentration induces a "cortical inhibition" which causes suppression of physiological electrical brain activity, the absence of EEG paroxysmal phenomena during myoclonic jerks, and explains the rarity of epileptic seizures.
70例因铋中毒性脑病入院的患者接受了多次临床和脑电图检查。所有患者均出现肌阵挛性抽搐，但脑电图从未出现阵发性特征。计算机断层扫描显示皮质密度增高。22例患者出现癫痫发作，但仅当血液中铋水平低于1500微克/升时才出现癫痫样脑电图模式。提示皮质细胞内铋浓度过高会引起“皮质抑制”，导致生理性脑电活动受到抑制，肌阵挛性抽搐时脑电图无阵发性现象，并解释了癫痫发作罕见的原因。
