已知序列DNA（fdDNA）的理论解链曲线和变性图谱。
Theoretical melting profiles and denaturation maps of DNA with known sequence: fdDNA.
作者信息
Vologodskii A V, Frank-Kamenetskii M D
出版信息
Nucleic Acids Res. 1978 Jul;5(7):2547-56. doi: 10.1093/nar/5.7.2547.
Abstract
Differential melting profiles and denaturation maps are calculated for fdDNA whose sequence of nucleotides has been determined recently. The melting profiles for the total DNA and a number of its restriction fragments are compared with experimental data taken from literature. The comparison enables one to correlate a number of peaks on experimental melting profiles with the melting out of concrete regions of the nucleotide sequence. For three fragments very strong end effects are demonstrated on both theoretical and experimental profiles. These anomalous end effects are shown to be connected with a region highly enriched with AT-pairs. A possible influence of the heterogeneity of stacking interaction on the results obtained is discussed in detail.
摘要
已针对核苷酸序列最近已确定的fdDNA计算了差异熔解曲线和变性图谱。将总DNA及其多个限制性片段的熔解曲线与从文献中获取的实验数据进行比较。通过这种比较，可以将实验熔解曲线上的多个峰与核苷酸序列具体区域的解链联系起来。对于三个片段，在理论和实验曲线上均显示出非常强的末端效应。这些异常末端效应被证明与富含AT碱基对的区域有关。详细讨论了堆积相互作用的异质性对所得结果可能产生的影响。
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本文引用的文献
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Theory of DNA melting curves.DNA熔解曲线理论
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