Lee H S
Ther Drug Monit. 1984;6(2):182-8. doi: 10.1097/00007691-198406000-00009.
In a study with 113 Asian children in which phenobarbitone was used as the sole antiepileptic drug in 75 children, including Chinese, Malays, and Indians, the mean phenobarbitone dosage required to produce a plasma level of 15 micrograms/ml was 5.2 mg/kg/day. While the mean plasma level/dose ratio varied, the differences between the three ethnic groups were not statistically significant. Also of little difference were the ratios between the male and female groups. For those patients with poor seizure control, however, the mean plasma level/dose ratio was significantly lower than in those whose seizures were controlled. Using additional anticonvulsant drugs concurrently with phenobarbitone in 40 children raised the mean plasma level/dose ratios significantly in each ethnic group. Further, the greater age level in those given additional antiepileptic drugs might have contributed slightly to a higher mean plasma level/dose ratio.
在一项针对113名亚洲儿童的研究中，75名儿童（包括中国人、马来人和印度人）将苯巴比妥作为唯一的抗癫痫药物，产生15微克/毫升血浆水平所需的苯巴比妥平均剂量为5.2毫克/千克/天。虽然平均血浆水平/剂量比有所不同，但三个种族群体之间的差异无统计学意义。男性和女性群体之间的比例也几乎没有差异。然而，对于那些癫痫控制不佳的患者，平均血浆水平/剂量比明显低于癫痫得到控制的患者。在40名儿童中同时使用苯巴比妥和其他抗惊厥药物，显著提高了每个种族群体的平均血浆水平/剂量比。此外，使用其他抗癫痫药物的儿童年龄较大，这可能对较高的平均血浆水平/剂量比有轻微影响。
