苯巴比妥用于既往未治疗的癫痫。
Phenobarbitone in previously untreated epilepsy.
作者信息
Feely M, O'Callagan M, Duggan B, Callaghan N
出版信息
J Neurol Neurosurg Psychiatry. 1980 Apr;43(4):365-8. doi: 10.1136/jnnp.43.4.365.
Abstract
In a prospective study we used phenobarbitone to treat 13 new patients with epilepsy (eight adults and five children). Full seizure control was achieved in 11 patients and poor compliance was documented in one of the remaining two patients (in both of whom seizures were reduced by over 50%). Doses sufficient to give mean steady state plasma levels of more than 43 mumol/l (10 microgram/ml) appeared to be associated with better seizure control than lower doses. No serious side effects were observed.
摘要
在一项前瞻性研究中，我们使用苯巴比妥治疗13例新发癫痫患者（8名成人和5名儿童）。11例患者实现了完全癫痫发作控制，其余2例中有1例记录到依从性差（这2例患者的癫痫发作均减少了50%以上）。与较低剂量相比，足以使平均稳态血浆水平超过43μmol/l（10μg/ml）的剂量似乎与更好的癫痫发作控制相关。未观察到严重副作用。
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