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[胺亚硝化反应抑制剂在人胃液及动物体内的作用]

[The action of inhibitors of the amine nitrosation reaction in human gastric juice and in the body of animals].

作者信息

Ermilov V B, Shendrikova I A, Dikun P P

出版信息

Vopr Onkol. 1989;35(1):38-44.

PMID:2919503
Abstract

The effect of ascorbic, ferulic and caffeic acids on dimethylamine and amidopyrine nitrosation in a medium containing 3 samples of total gastric juice taken from 10 humans (pH = 6.1; 3.2 and 1.7) was studied versus the amount of inhibitor added to the medium. The resultant relationship proved bizarre, the inhibitor at low concentrations stimulating nitrosation in some situations. When gastric juice concentration in the medium was further lowered by dilution with a buffer at relevant value of pH, the paradoxical effect of inhibition gradually disappeared.

摘要

研究了抗坏血酸、阿魏酸和咖啡酸对取自10名人类的3份全胃液样本(pH = 6.1;3.2和1.7)中二甲胺和氨基比林亚硝化作用的影响,与添加到培养基中的抑制剂数量进行对比。结果显示的关系很奇怪,在某些情况下低浓度抑制剂会刺激亚硝化作用。当用具有相关pH值的缓冲液稀释培养基中的胃液浓度时,这种矛盾的抑制作用逐渐消失。

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1
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