Pörsti I, Ylitalo P
Acta Physiol Scand. 1984 Mar;120(3):387-91. doi: 10.1111/j.1748-1716.1984.tb07399.x.
Acute hypertension impairs the function of biological barriers, e.g. that of blood-brain barrier. We tested the hypothesis that chronic hypertension might influence the penetration of compounds through blood-brain and blood-testis barriers. With this in mind, the penetration of relatively small radioactive compounds (14C-2-methyl-4-chlorophenoxyacetic acid = 14C-MPA, 14C-sucrose and 14C-antipyrine, 5 microCi/kg intravenously) into the brain, liquor space and testis was compared in male normotensive (Wistar and chronically hypertensive SH rats (11-22 months old). In chronic hypertension after 14C-MCPA and 14C-sucrose administration the penetration of radioactivity into the brain, cerebrospinal fluid and testis had significantly decreased or showed evidence of decrease, while after 14C-antipyrine administration the penetration remained unchanged. Penetration of Evans blue-albumin complex into the brain was studied by giving intravenous injection of Evans blue (5% solution) which is firmly bound to serum albumin. Extravasation of dye-protein complex into the brain showed no difference between Wistar and SH rats. The results suggest that chronic hypertension does not increase the penetration of compounds into the brain and testis but rather, reduces it.
急性高血压会损害生物屏障的功能，例如血脑屏障的功能。我们检验了慢性高血压可能会影响化合物透过血脑屏障和血睾屏障的这一假说。考虑到这一点，我们比较了相对较小的放射性化合物（14C-2-甲基-4-氯苯氧乙酸 = 14C-MPA、14C-蔗糖和14C-安替比林，静脉注射5微居里/千克）在雄性正常血压（Wistar）大鼠和慢性高血压SH大鼠（11 - 22月龄）脑中、脑脊液间隙和睾丸中的渗透情况。在慢性高血压大鼠中，给予14C-MCPA和14C-蔗糖后，放射性物质在脑、脑脊液和睾丸中的渗透显著降低或有降低的迹象，而给予14C-安替比林后，其渗透保持不变。通过静脉注射与血清白蛋白紧密结合的伊文思蓝（5%溶液）来研究伊文思蓝 - 白蛋白复合物在脑中的渗透情况。染料 - 蛋白质复合物向脑内的外渗在Wistar大鼠和SH大鼠之间没有差异。结果表明，慢性高血压不会增加化合物在脑和睾丸中的渗透，反而会降低其渗透。
