Abela G S, Conti C R, Normann S, Feldman R L, Pepine C J
Am J Cardiol. 1984 Jul 1;54(1):200-5. doi: 10.1016/0002-9149(84)90329-1.
A model for testing transluminal recanalization techniques was developed. Human atherosclerotic arteries were transplanted in dogs and evaluated by angiographic and histologic study within a 12-week period. An inflammatory response was most intense within the first 2 weeks. By 12 weeks, no inflammation was noted. The model has several advantages: (1) The pathologic characteristics are those of a human coronary artery. (2) Thrombus formation is frequent, with progression to a well organized dense fibrocellular vascular occlusion within 4 to 12 weeks. (3) The arterial occlusion resembles human vascular disease. (4) The vascular occlusions are readily accessible with standard catheterization technique. (5) The model is easy to produce within a short period. This model has been used to evaluate laser recanalization of vascular obstructions.
开发了一种用于测试腔内再通技术的模型。将人类动脉粥样硬化动脉移植到狗体内，并在12周内通过血管造影和组织学研究进行评估。炎症反应在最初2周内最为强烈。到12周时，未观察到炎症。该模型具有几个优点：（1）病理特征与人类冠状动脉相同。（2）血栓形成频繁，在4至12周内进展为组织良好的致密纤维细胞性血管闭塞。（3）动脉闭塞类似于人类血管疾病。（4）血管闭塞可通过标准导管技术轻松到达。（5）该模型易于在短时间内制作。该模型已用于评估血管阻塞的激光再通。
