Schoeller D A, Webb P
Am J Clin Nutr. 1984 Jul;40(1):153-8. doi: 10.1093/ajcn/40.1.153.
Previous studies have indicated that the doubly labeled water method can be used to measure energy expenditure in free-living humans. In this study, we compare the doubly labeled water method with nearly continuous respiratory gas exchange in five healthy adults. Total body water and isotope elimination rates were determined by mass spectrometric analysis of urinary water after the administration of 2H2 18O. Respiratory gas exchange was measured 22 to 23 h/day for 5 consecutive days. Energy expenditures from the doubly labeled water method averaged 6% more than those from respiratory gas exchange with an 8% coefficient of variation.
以往的研究表明，双标记水法可用于测量自由生活状态下人体的能量消耗。在本研究中，我们对5名健康成年人的双标记水法与近乎连续的呼吸气体交换法进行了比较。给予2H2 18O后，通过对尿水进行质谱分析来测定总体水和同位素消除率。连续5天每天22至23小时测量呼吸气体交换。双标记水法测得的能量消耗平均比呼吸气体交换法高6%，变异系数为8%。
