Agner T G, Balster R L
Pharmacol Biochem Behav. 1978 May;8(5):593-6. doi: 10.1016/0091-3057(78)90393-3.
levo-alpha-Acetylmethadol was orally administered via a sucrose solution to rats in their drinking water for 24 days. A control group received only sucrose. Bodyweight and fluid consumption were monitored daily. The behavioral effects during chronic drug administration and during eight days of withdrawal were studied using behavior controlled by a fixed-interval schedule of food reinforcement. Body weights of treated animals remained stable during drug administration but decreased by approximately 25% during withdrawal. There were no significant differences in volume of fluid consumed by the two groups. Response rate and number of reinforcements were decreased during drug administration. During withdrawal, response rates were greater than pre-drug control rates.
将左旋α-乙酰美沙多通过蔗糖溶液混入大鼠饮用水中口服给药24天。对照组只给予蔗糖。每天监测体重和液体摄入量。使用由固定间隔食物强化时间表控制的行为，研究慢性给药期间和停药8天期间的行为效应。给药期间，治疗组动物体重保持稳定，但停药期间体重下降了约25%。两组的液体摄入量没有显著差异。给药期间反应率和强化次数降低。停药期间，反应率高于给药前的对照率。
