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[重症监护病房新生儿中抗生素耐药微生物的分布情况]

[Distribution of antibiotic-resistant microorganisms among newborn infants in an intensive care unit].

作者信息

Kudinova T I, Voropaeva S D, Maĭorova V N

出版信息

Antibiotiki. 1984 May;29(5):382-6.

PMID:6742811
Abstract

Bacteriological assay of the nasal, fauces and feces microflora of 40 newborns of the Department of Intensive Therapy revealed their primary colonization with various opportunistic microorganisms from the environment. Sensitivity of the isolates to 15 antibiotics was tested. It was shown that multiple resistance strains predominated. The staphylococcal strains were mainly resistant to benzylpenicillin, ampicillin, erythromycin and polymyxin. The enterococci were most frequently resistant to methicillin, lincomycin, kanamycin, monomycin and neomycin. Tetracycline and chloramphenicol resistant strains of E. coli were detected. Marked resistance to carbenicillin, ampicillin, cephuroxim and cephaloridin and high sensitivity to cephotaxim and gentamicin were determined in the Klebsiella strains with the method of serial dilutions on solid media. The presence of opportunistic microorganisms with multiple resistance to antibiotics, ate appearance of the own microflora and decreased immunological defence may be the cause of infection in newborns of departments of intensive therapy. Circulation of antibiotic-resistant strains in departments for newborns is fraught with a threat of hospital infections.

摘要

对重症治疗科40名新生儿的鼻腔、咽喉和粪便微生物群进行细菌学检测,发现他们最初被来自环境的各种机会性微生物定植。对分离出的菌株进行了对15种抗生素的敏感性测试。结果表明,多重耐药菌株占主导。葡萄球菌菌株主要对苄青霉素、氨苄青霉素、红霉素和多粘菌素耐药。肠球菌最常对甲氧西林、林可霉素、卡那霉素、莫能霉素和新霉素耐药。检测到对四环素和氯霉素耐药的大肠杆菌菌株。采用固体培养基连续稀释法测定了克雷伯菌属菌株对羧苄青霉素、氨苄青霉素、头孢呋辛和头孢菌素的显著耐药性以及对头孢噻肟和庆大霉素的高敏感性。存在对多种抗生素耐药的机会性微生物、自身微生物群的出现以及免疫防御能力下降可能是重症治疗科新生儿感染的原因。新生儿科室中抗生素耐药菌株的传播存在医院感染的威胁。

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