类风湿关节炎患者的血浆锌及其与临床症状和药物治疗的关系
Plasma zinc and its relationship to clinical symptoms and drug treatment in rheumatoid arthritis.
作者信息
Balogh Z, El-Ghobarey A F, Fell G S, Brown D H, Dunlop J, Dick W C
出版信息
Ann Rheum Dis. 1980 Aug;39(4):329-32. doi: 10.1136/ard.39.4.329.
Total plasma zinc levels in patients with rheumatoid arthritis on different therapeutic treatments were determined in conjunction with total serum proteins, serum albumin and globulin, and articular index of joint tenderness, erythrocyte sedimentation rate, rheumatoid factor, serum copper, and serum iron. There were significantly lower zinc levels in patients with rheumatoid arthritis on nonsteroidal anti-inflammatory drugs than in patients on levamisole and penicillamine. Zinc levels correlated positively with serum albumin, and there was an inverse correlation between zinc levels and both ESR and globulin concentration in all rheumatoid patients. However, the correlation coefficient varied in the different treatment groups. The results of this study support the hypothesis that low plasma zinc level in rheumatoid arthritis is one of the nonspecific features of inflammation.
测定了接受不同治疗的类风湿性关节炎患者的血浆总锌水平，并同时测定了总血清蛋白、血清白蛋白和球蛋白、关节压痛的关节指数、红细胞沉降率、类风湿因子、血清铜和血清铁。使用非甾体抗炎药治疗的类风湿性关节炎患者的锌水平显著低于使用左旋咪唑和青霉胺治疗的患者。锌水平与血清白蛋白呈正相关，在所有类风湿性关节炎患者中，锌水平与红细胞沉降率和球蛋白浓度均呈负相关。然而，不同治疗组的相关系数有所不同。本研究结果支持以下假设：类风湿性关节炎患者血浆锌水平低是炎症的非特异性特征之一。
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