• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一系列新型吡啶鎓衍生物对氟斯的明抑制乙酰胆碱酯酶的保护作用。

Protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase by fluostigmine.

作者信息

Faff J, Raszewski W, Rump S

出版信息

Pharmazie. 1978 Feb-Mar;33(2-3):120-1.

PMID:674296
Abstract

The protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase (AChE) by fluostigmine was studied in vitro on human erythrocytes. It was stated that some of these compounds exhibit protective action for AChE against inhibition by fluostigmine. The best protective index had N-methyl-4-[gamma-pyridyl]-pyridinium iodide.

摘要

在体外对人红细胞研究了一系列新型吡啶鎓衍生物对毒扁豆碱抑制乙酰胆碱酯酶(AChE)的保护作用。结果表明,其中一些化合物对AChE具有抵抗毒扁豆碱抑制的保护作用。最佳保护指数的是N-甲基-4-[γ-吡啶基]-碘化吡啶鎓。

相似文献

1
Protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase by fluostigmine.一系列新型吡啶鎓衍生物对氟斯的明抑制乙酰胆碱酯酶的保护作用。
Pharmazie. 1978 Feb-Mar;33(2-3):120-1.
2
Protective action of series of new mono-pyridinium salts and their effect on "aging" of acetylcholine esterase inhibited by fluostigmine.一系列新型单吡啶鎓盐的保护作用及其对被毒扁豆碱抑制的乙酰胆碱酯酶“老化”的影响。
Pol J Pharmacol Pharm. 1977 Nov-Dec;29(6):603-7.
3
Antidotal efficacy of pyridinium chloride derivatives against soman poisoning.氯化吡啶鎓衍生物对梭曼中毒的解毒效果。
Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):17-21. doi: 10.1111/j.1742-7843.2006.pto_385.x.
4
[Relation between chemical structure and cholinesterase-reactivating effect in a series of new asymmetric pyridinium salts. I. Derivatives of 4-hydroxyiminomethylpyridine].[一系列新型不对称吡啶鎓盐的化学结构与胆碱酯酶复活作用的关系。I. 4-羟基亚胺甲基吡啶的衍生物]
Arzneimittelforschung. 1970 Jan;20(1):55-62.
5
Protective effect of some pyridinium salts on acetylcholinesterase against organophosphate inhibition.某些吡啶盐对乙酰胆碱酯酶抵抗有机磷酸酯抑制的保护作用。
Acta Physiol Pol. 1980 Jan-Feb;31(1):93-9.
6
Potential acetylcholinesterase reactivators: oxime and amidoxime derivatives.潜在的乙酰胆碱酯酶复活剂:肟类和偕胺肟衍生物。
Arch Immunol Ther Exp (Warsz). 1976;24(6):901-10.
7
Protective effect of bis-pyridinium compounds on the rat brain acetylcholinesterase inhibition by carbamate in vitro.
Biomed Biochim Acta. 1987;46(6):455-9.
8
In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity.吡啶肟类化合物的体外和体内评价:与乙酰胆碱酯酶的相互作用模式、对塔崩和梭曼中毒小鼠的影响及其细胞毒性。
Toxicology. 2006 Feb 15;219(1-3):85-96. doi: 10.1016/j.tox.2005.11.003. Epub 2005 Dec 5.
9
Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning.用吡啶肟进行预处理可改善对塔崩中毒的解毒治疗。
Toxicology. 2006 Nov 10;228(1):41-50. doi: 10.1016/j.tox.2006.08.012. Epub 2006 Aug 18.
10
Reactivating and protective effects of pyridinium compounds in human erythrocyte acetylcholinesterase inhibition by organophosphates in vitro.吡啶鎓化合物对有机磷酸酯体外抑制人红细胞乙酰胆碱酯酶的复活及保护作用
Arch Toxicol. 1980 May;45(1):21-7. doi: 10.1007/BF00303291.