Gajewski D, Owczarczyk H
Acta Physiol Pol. 1980 Jan-Feb;31(1):93-9.
The protective effect of ten new synthetized mono- and bis-pyridinium salts on acetylcholinesterase (AChE) against DFP, Chlorphenvinphos, DDVP, IPO 62 and IPO 63 inhibition in vitro and in mice i.p. was studied. Moreover, abolition of tetanic block of the tibialis anterior muscle in rats after intoxication with DDVP by these salts was tested. An increase of the therapeutic effect of atropine after DFP poisoning in mice and a rise of LD50 values from 1.4 (PAN-W-15) to 5.1 times (PAN-W-14) was noted. The effect of PAN-W-14 and PAN-W-18 after inhibition by other organophosphates was found to be highest in human erythrocytes in vitro. In addition, prophylactic administration of PAN-W-14 prevented the tetanic block of the muscle in situ after DDVP intoxication.
研究了十种新合成的单吡啶盐和双吡啶盐对乙酰胆碱酯酶（AChE）在体外及小鼠腹腔注射时抵抗二异丙基氟磷酸酯（DFP）、毒虫畏、敌敌畏、IPO 62和IPO 63抑制的保护作用。此外，还测试了这些盐对大鼠经敌敌畏中毒后胫骨前肌强直阻滞的消除作用。注意到在小鼠DFP中毒后阿托品的治疗效果有所增加，半数致死量（LD50）值从1.4倍（PAN-W-15）提高到5.1倍（PAN-W-14）。发现PAN-W-14和PAN-W-18在体外对人红细胞受其他有机磷酸酯抑制后的作用最为显著。此外，预先给予PAN-W-14可预防敌敌畏中毒后肌肉的原位强直阻滞。
