LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Molecules. 2020 Dec 12;25(24):5886. doi: 10.3390/molecules25245886.
The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole derivatives that contain a styryl (2-arylvinyl) group linked in different positions of the pyrazole backbone. Although there are studies on the synthesis of styrylpyrazoles dating back to the 1970s and even earlier, this type of compound has rarely been studied. This timely review intends to summarize the properties, biological activity, methods of synthesis and transformation of styrylpyrazoles; thus, highlighting the interest and huge potential for application of this kind of compound.
由于其显著的生物活性，吡唑核及其还原形式，吡唑啉和吡唑烷，是药物化学中的重要骨架。随着时间的推移，已经研究和报道了大量的吡唑衍生物。本文综述了吡唑衍生物，其中包含一个苯乙烯基（2-芳基乙烯基）基团，连接在吡唑主链的不同位置。尽管早在 20 世纪 70 年代甚至更早，就有关于苯乙烯基吡唑的合成研究，但这种化合物很少被研究。这篇及时的综述旨在总结苯乙烯基吡唑的性质、生物活性、合成和转化方法；从而突出了这种化合物的应用兴趣和巨大潜力。
