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生长的自分泌调节：II. 糖皮质激素抑制c-sis癌基因特异性RNA转录物的转录。

Autocrine regulation of growth: II. Glucocorticoids inhibit transcription of c-sis oncogene-specific RNA transcripts.

作者信息

Norris J S, Cornett L E, Hardin J W, Kohler P O, MacLeod S L, Srivastava A, Syms A J, Smith R G

出版信息

Biochem Biophys Res Commun. 1984 Jul 18;122(1):124-8. doi: 10.1016/0006-291x(84)90448-0.

DOI:10.1016/0006-291x(84)90448-0
PMID:6743325
Abstract

The ductus deferens smooth muscle tumor cell line (DDT1MF-2) expresses c-sis proto-oncogene poly A+ RNA transcripts which are thought to encode at least one subunit of the potent mitogen platelet derived growth factor (PDGF). We have previously demonstrated that glucocorticoids block DDT1MF-2 cells in G0/G1 stage of the cell cycle, and that exogenously applied PDGF reinitiates cell cycle progression. In this paper we document that glucocorticoids act to inhibit cell cycle progression by inhibiting the expression of c-sis poly A+ transcripts, which we suggest are encoding a PDGF-like molecule for DDT1MF-2 cells.

摘要

输精管平滑肌肿瘤细胞系（DDT1MF-2）表达c-sis原癌基因多聚腺苷酸加尾RNA转录本，这些转录本被认为至少编码强效有丝分裂原血小板衍生生长因子（PDGF）的一个亚基。我们之前已经证明，糖皮质激素可将DDT1MF-2细胞阻滞在细胞周期的G0/G1期，并且外源性应用PDGF可重新启动细胞周期进程。在本文中，我们证明糖皮质激素通过抑制c-sis多聚腺苷酸加尾转录本的表达来抑制细胞周期进程，我们认为这些转录本为DDT1MF-2细胞编码一种类PDGF分子。

相似文献

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Autocrine regulation of growth: II. Glucocorticoids inhibit transcription of c-sis oncogene-specific RNA transcripts.生长的自分泌调节：II. 糖皮质激素抑制c-sis癌基因特异性RNA转录物的转录。
Biochem Biophys Res Commun. 1984 Jul 18;122(1):124-8. doi: 10.1016/0006-291x(84)90448-0.
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引用本文的文献

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Do you know the sex of your cells?你的细胞知道自己的性别吗？
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2
Glucocorticoids induce a 29 000 Mr protein in DDT1 MF-2 smooth muscle cells but not in the DDT1 MF-2 GR glucocorticoid resistant variant.
Mol Cell Biochem. 1985 Sep;68(1):79-85. doi: 10.1007/BF00219391.
3
Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like protein.大鼠骨骼肌成肌细胞和动脉平滑肌细胞表达血小板衍生生长因子（PDGF）A链的基因，但不表达B链（c-sis）的基因，并产生一种类PDGF蛋白。
Proc Natl Acad Sci U S A. 1986 Sep;83(18):6844-8. doi: 10.1073/pnas.83.18.6844.
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Rapid regulation of c-myc protooncogene expression by progesterone in the avian oviduct.孕酮对禽类输卵管中c-myc原癌基因表达的快速调控。
Proc Natl Acad Sci U S A. 1988 Mar;85(6):1796-800. doi: 10.1073/pnas.85.6.1796.
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Glucocorticoid induction of beta-adrenergic receptors in the DDT1 MF-2 smooth muscle cell line involves synthesis of new receptor.糖皮质激素诱导DDT1 MF - 2平滑肌细胞系中的β - 肾上腺素能受体涉及新受体的合成。
Mol Cell Biochem. 1987 Mar;74(1):21-7. doi: 10.1007/BF00221909.
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Oncogene-related growth factors and growth factor receptors in human malignant glioma-derived cell lines.人恶性胶质瘤衍生细胞系中的癌基因相关生长因子和生长因子受体
J Neurooncol. 1989 May;7(1):47-56. doi: 10.1007/BF00149378.
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Rapid induction of the c-jun protooncogene in the avian oviduct by the antiestrogen tamoxifen.抗雌激素他莫昔芬可快速诱导禽类输卵管中的c-jun原癌基因。
Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):829-33. doi: 10.1073/pnas.88.3.829.
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Glucocorticoids have opposite effects on ornithine decarboxylase and cell growth in pancreatic acinar AR42J cells.糖皮质激素对胰腺腺泡AR42J细胞中的鸟氨酸脱羧酶和细胞生长具有相反的作用。
Yale J Biol Med. 1992 Sep-Oct;65(5):449-56; discussion 465-9.