普萘洛尔、阿替洛尔和拉贝洛尔对正常受试者安替比林动力学的短期影响。
The short term effects of propranolol, atenolol and labetalol on antipyrine kinetics in normal subjects.
作者信息
Daneshmend T K, Roberts C J
出版信息
Br J Clin Pharmacol. 1982 Jun;13(6):817-20. doi: 10.1111/j.1365-2125.1982.tb01872.x.
Abstract
1 The effects of three day courses of propranolol 40 mg three times daily, atenolol 100 mg twice daily and labetalol 100 mg three times daily on antipyrine kinetics were examined in 13 normal subjects. 2 The mean antipyrine clearance initially was 41.3 +/- 12.4 ml/min (mean +/- s.d.) and fell to 35.0 +/- 12.1 ml/min following propranolol (P less than 0.025), 34.5 +/- 9.5 ml/min following atenolol (P less than 0.01), and 35.2 +/- 8.6 ml/min following labetalol (P less than 0.05). 3 The prolongation in antipyrine half-life was significant only following atenolol. Propranolol only caused a significant reduction in the volume of distribution of antipyrine. 4 These adrenoceptor antagonists appear to decrease antipyrine clearance in normal subjects. The reduction in antipyrine clearance was similar with all three drugs and appeared to be independent of the differing lipid solubilities and pharmacological profiles of the adrenoceptor antagonists examined.
摘要
- 在13名正常受试者中研究了每日三次服用40毫克普萘洛尔、每日两次服用100毫克阿替洛尔以及每日三次服用100毫克拉贝洛尔的三日疗程对安替比林动力学的影响。2. 安替比林的平均清除率最初为41.3±12.4毫升/分钟（平均值±标准差），服用普萘洛尔后降至35.0±12.1毫升/分钟（P<0.025），服用阿替洛尔后降至34.5±9.5毫升/分钟（P<0.01），服用拉贝洛尔后降至35.2±8.6毫升/分钟（P<0.05）。3. 仅在服用阿替洛尔后，安替比林半衰期的延长具有显著意义。普萘洛尔仅使安替比林的分布容积显著降低。4. 这些肾上腺素能受体拮抗剂似乎会降低正常受试者的安替比林清除率。三种药物对安替比林清除率的降低相似，且似乎与所研究的肾上腺素能受体拮抗剂不同的脂溶性和药理特性无关。
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本文引用的文献
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Antipyrine metabolism during the menstrual cycle.月经周期中的安替比林代谢
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Reduction in lidocaine clearance during continuous infusion and by coadministration of propranolol.连续输注利多卡因以及与普萘洛尔合用时，利多卡因清除率降低。
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Inhibition of antipyrine metabolism by beta-adrenoceptor antagonists.β-肾上腺素能受体拮抗剂对安替比林代谢的抑制作用。
Br J Clin Pharmacol. 1981 Dec;12(6):779-84. doi: 10.1111/j.1365-2125.1981.tb01306.x.
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Comparison of plasma levels of antipyrine, tolbutamide, and warfarin after oral and intravenous administration.口服和静脉注射后安替比林、甲苯磺丁脲和华法林的血浆水平比较。
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Effect of different beta-adrenergic receptor blocking agents on hexobarbital induced narcosis in mice.不同β-肾上腺素能受体阻断剂对小鼠己巴比妥诱导麻醉的影响。
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The antipyrine test in clinical pharmacology: conceptions and misconceptions.临床药理学中的安替比林试验：概念与误解
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