[三甲卡因聚合物化合物的局部麻醉特性]
[Local anesthetic properties of a polymeric compound of trimecaine].
作者信息
Ignatov Iu D, Vasil'ev Iu N, Shal'nova L I, Trofimova E L, Makarov K A
出版信息
Biull Eksp Biol Med. 1984 Jun;97(6):686-8.
Original techniques were used in experiments on rabbits and rats to explore the activity and duration of a local anesthetic action of a new trimecaine polymer as compared with trimecaine hydrochloride. The polymer effect was found to be 1.5-2 times longer as compared to that of its low-molecular analog, which was discovered in experimental terminal, conduction and infiltration anesthesia in particular. According to the data obtained, the prolongation of the effect of the new drug is determined by slow separation of trimecain from the polymer.
采用原技术对家兔和大鼠进行实验，以探究一种新型三甲卡因聚合物与盐酸三甲卡因相比的局部麻醉作用活性和持续时间。结果发现，该聚合物的作用效果与其低分子类似物相比长1.5至2倍，这一现象尤其在实验性末梢麻醉、传导麻醉和浸润麻醉中被发现。根据所获得的数据，新药作用效果的延长是由三甲卡因从聚合物中的缓慢分离所决定的。
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