[The local anesthetic activity of inclusion compounds of pirbentan and trimecaine with beta-cyclodextrin].

Whether the prolonged action of the topical anesthetics trimecaine and pirbentan can be achieved by using inclusion compounds was studied. beta-Cyclodextrin was used as an agent containing topical anesthetics in its molecule. In in vitro and in vivo experiments, the inclusion compounds trimecaine and pirbentan with beta-cyclodextrin produced a more prolonged action in terminal anesthesia than the compounds used alone.